The Navier-Stokes problem mentioned in the movie is one of the seven Millennium Prize problems in mathematics. Clay Mathematics Institute offered a USD 1,000,000 prize to the first person providing a solution for a specific problem statement.
As a result of several scene retakes from multiple angles, the knitter in the hospital scene background had to keep unraveling her work between takes to maintain continuity.
John Krasinski, who is good friends with fellow Bostonian Chris Evans, provided the voice to the MIT operator at the end of the film.
After filming had ended, Chris Evans and Jenny Slate began a relationship and broke up almost a year later. In November of 2017, however, they had gotten back together before breaking up again in March of 2018.