The TV movie is dedicated to Roberta Custer, who was William Petersen's personal assistant all along his career. She died during the filming.
Due to an error by Latinamerican broadcaster AXN, the first part of the series finale wasn't released on its premiere date (despite heavy promotion). Instead, the pay channel broadcast the second part of this finale twice.
Gil Grissom's boat is called the "Ishmael". Reference to Moby Dick character.
Ted Danson and William Petersen both starred in the movie Cousins (1989). Their characters had affairs with each other's wives.