Reese Witherspoon replaced Natalie Portman in the lead role but dropped out to focus on season 2 of Big Little Lies (2017). Later, Portman returned in the lead role.
Retired astronaut Marsha Ivins criticized the premise of the plot and denied that there is such a thing as a "longstanding idea that says astronauts begin to lose their grip on reality after being in space for an extended period of time".
The original title was Pale Blue Dot. This name is a reference to a famous narration made by Carl Sagan after a photo of planet Earth taken on February 14, 1990 by space probe Voyager 1 at 3.7 billion miles or 6 billion kilometers (its last photo before NASA turned off the camera on Voyager 1), where planet Earth can be seen as a small blue dot in the middle of a ray sun.