Robert Zemeckis said that he would never make a Back to the Future Part IV, but this game was very close to what a fourth movie would have been like.
This game featured voice work by Tom Wilson, replacing the voice work for Biff, as originally done by "Kid Beyond" Andrew Chaikin for the previously released episodic games. Contrary to popular belief, Wilson did not re-voice the other Tannen characters in the game.
If you talk to the squawk box outside the McFly residence in episode three, Marty says, "Everything is perfectly fine now...we're fine....how are you?!" which is a reference to Han Solo's interaction with the Stormtrooper on the radio in Star Wars: Episode IV - A New Hope (1977).
In Episode 1, when Edna Strickland is shouting out her window with a megaphone, she says, "Jack! Diane! I know what you're doing behind that tree!" This is a reference to the John Mellencamp song "Jack and Diane" where Jack suggest that he and Diane run behind some trees.
When Marty first travels back to 1931, the billboard that Marty hides the Delorean behind states that the Hill Valley Exposition was scheduled to take place that Fall in Hill Valley's Courthouse Square. However, either Hill Valley's town council or the game makers must have had a change of heart, as the Expo ultimately ends up taking place at the Hill Valley High School.