This is the first Disney XD spin off that combines two shows into one.
First spinoff series on Disney XD.
Spencer Boldman and Tyrel Jackson Williams from Lab Rats (2012) (Adam and Leo respectively) do not return, as explained in the show's series finale.
Kaz's little brother, Kyle, will be on it
While numerous Lab Rats (2012) characters make guest appearances, apart from the main three leads, no characters from Mighty Med (2013) make any appearances, and are hardly referenced, likely due to the fact that the writing staff is made up of only writers from Lab Rats.