The two old men watching Melissa McCarthy and Maya Rudolph play racquetball are the fathers of McCarthy and her husband, director Ben Falcone.
The campus of Agnes Scott College was used for the fictional "Decatur University." Agnes Scott is in the city of Decatur, Georgia.
Christina Aguilera visited the set after her scene was filmed and had drinks with the cast, and Melissa McCarthy thought the singer was "so amazing" for that.
In the film, Melissa McCarthy's character's parents are named Mike and Sandy. These are also the names of McCarthy's real-life parents.
Husband and wife actors Ben Falcone and Melissa McCarthy have appeared in several movies together including: The Nines (2007), Bridesmaids (2011), Identity Thief (2013), The Heat (2013), Tammy (2014), Spy (2015) and The Boss (2016).