The scene where Andrew Saul takes 16,000mg of Vitamin C in one go (about 51mins into the film), the directors considered having to shoot part of the scene again. Andrew immediately offered to take another 16g! That's 32,000mg in one go! the directors told him not to worry, they could work with what they had but they couldn't believe that he could take that much in one go without exploding! He did not have to run to the toilet after 16g. The fact that he offered to take 32g means he knew he could without any adverse side effects which blew their minds.