Amy Sherman-Palladino explained the show concept as follows: "I wanted to do a story about a woman who thought she'd scored...She'd gotten it all, and then, bam, it all falls apart. And in falling apart, she discovers an ambition and a need to speak, and a voice that she just frankly didn't know was there."
When Midge and Lenny meet up at the bar in It's Comedy or Cabbage (2019), before going to the filming of Miami After Dark, a fan walks up to Lenny, calling him "Mr. Bruce." Lenny responses "Mr. Bruce was my mother." Amy Sherman-Palladino (creator/producer/director of the show) knew Sally Marr, who was the real Lenny Bruce's mother and whenever anyone learned who she was, she'd call herself "Mr. Bruce", so the line's in reference to this.
The first TV show on a streaming platform (Amazon Prime) to win the Emmy for Outstanding Comedy Series.
In a 2018 interview, Rachel Brosnahan said that gratuitous nudity in general frustrates her because it's tiring and distracts from storytelling, but she gladly got naked in the pilot because she thought it was funny. She said it wasn't about sex or being sexualized. Her character was just hitting a bottom she couldn't have imagined.
Rachel Brosnahan (Miriam 'Midge' Maisel) and Jason Ralph (Mike Carr) are husband and wife in real life.