The series was originally filmed with Ed Westwick playing Mickey Argyll, and was scheduled to air around the Christmas season of 2017. However in November 2017, the British Broadcasting Corporation announced that it would not broadcast the series while an investigation into Westwick on allegations of serious sexual assault was ongoing. In January 2018, the BBC announced that they were commencing re-shoots with Christian Cooke replacing Westwick.
The decision to re-shoot Ed Westwick's scenes with a new actor caused continuity problems, as the series had been originally shot in the Summer of 2017 but the re-shot scenes were now taking place over 12 days in January 2018, during a particularly cold and snowy winter period.The entire re-shoot cost in excess of 2 million pounds.
Although writer Sarah Phelps often spoke admiringly of Agatha Christie, this adaptation bears almost no relation whatever to Christie's novel, altering most of the characters and even changing the solution to the mystery. Many Christie admirers felt that she had treated the source novel with contempt.
Screenwriter, Sarah Phelps, admitted that she had never read any of Agatha Christie's stories, nor had she ever watched any Agatha Christie film or TV adaptions, until she read And Then There Were None for the purpose of adapting it to the screen. Witness for the Prosecution and Ordeal by Innocence were her second and third screenplays.
Catherine Keener was originally cast to play Rachael Argyll before Anna Chancellor took in the role.