The number on Mickey Mouse's racer matches the last two numbers of the year the first animated cartoon with him was shown in public for the first time Steamboat Willie (1928).
The first television series starring Donald Duck in which Tony Anselmo doesn't voice him. Here, Donald is voiced by newcomer, Daniel Ross since Tony Anselmo was too busy voicing Donald in other projects. Anselmo wasn't happy about his role being recast.
Due to the recent death of Russi Taylor, the show was on hiatus until they could find the new voice artist for Minnie Mouse. In 2020, Kaitlyn Robrock became the new voice of Minnie Mouse.
The series title was originally Mickey and the Roadster Racers but was changed to Mickey Mouse Mixed-Up Adventures during the release of Season 3. On Disney+ it's a separate series.
Unlike the total cast of Mickey Mouse Clubhouse (2006), this show had almost a total of 100 voice actors.