Caylee Blosenski portrays a paraplegic character in the movie. While not paraplegic in real life, Blosenski lost one leg to cancer.
The second remake of the original Cheaper by the Dozen (1950). The first remake was Cheaper by the Dozen (2003), starring Steve Martin.
On the podcast Fake Doctors, Real Friends with Zach and Donald (2020), Zach Braff revealed that during filming, the Rottweiler actually bit Braff once between takes.
Baker's Breakfast is renamed Baker's Dozen, a wordplay on the idiom meaning 12 plus 1 (one being Seth).