In an AOL Radio listener's poll, "Nobody's Home" was voted Lavigne's seventh best song.
During the video Avril was wearing the T-shirt with logo of Moscow. Russian word "Moskva" was printed on Avril's T-shirt.
"Nobody's Home" is a "rock ballad" oriented song and is generally slower paced than her previous singles from Under My Skin.
The song was very close to reaching the top 40 of the Billboard Hot 100, but it only managed to peak at No. 41.
In the UK and Australia, the track reached No. 24 in both countries; it was Lavigne's lowest-charting UK single before "Hot" charted in 2007 and peaked only at No. 30.