The music video was inspired by the One-Minute Sculptures of Erwin Wurm.
"Can't Stop" is one of the most played songs by Red Hot Chili Peppers on a live stage.
"Can't Stop" has been performed over 530 times since 2002 making it one of the band's most performed songs and as of 2017 has remained as the band's opening song for many of their shows.
Mark Romanek instructed John Frusciante to mime playing an orange Toronado guitar as it fit with the color scheme of the video. However, Frusciante stated he would never play this type of guitar model as he only plays older, vintage guitars.
The lighting was positioned in order to provide a clean-cut, contemporary atmosphere which would integrate with the video's concept.