The film's titles in various Latin American countries translate to "Sexy by Accident".
The poster at the event during Renee's final speech is entitled "Celebrating 50 years of Beauty". It depicts a famous photo of Lauren Hutton (who plays Lilly Leclair) in 1974.
Actresses Michelle Williams and Busy Philipps are best friends in real life. They also worked together on Dawson's Creek (1998).
The film was written by Marc Silverstein, his wife, Busy Phillips, stars as one of Amy Schumer's friends. In He's Just Not That Into You (2009), Marc wrote and Busy co-starred as well.
STXfilms moved the release date up from June 29, 2018 to April 27, 2018 due to positive reception to the first trailer and a positive test screening. However, the release date was later moved up a week to April 20, 2018 to avoid competition with Avengers: Infinity War (2018) after Marvel Studios announced it would be released worldwide on April 27, 2018 instead of May 4, 2018 in the United States.