The cruiseship portion of the film was delayed by Hurricane Irma. The cast and crew were evacuated to Disney World.
Lauren Miller Rogen was initially nervous about directing her husband, Seth Rogen. However, as soon as he was on set with her, she was completely calm, exclaiming "there's no one I trust more than him in the world."
The brunette woman who Jeff (Seth Rogan) is serenading during the karaoke competition is Lauren Miller Rogan-Seth Rogan's wife and director of this movie.
The line about Jeff (Seth Rogen) never smoking was already in the script prior to Seth Rogen being hired. It was initially meant as a sincere insight into Jeff's character; however the line then became humorous because of Seth's trademark of smoking marijuana.
The last scene in the film is in front of Harry's "Los Angeles" home, it is actually located in Miami Beach, Florida on Sunset Island II. It makes sense, since Royal Caribbean's Harmony of the Seas actually sails from Miami, Florida.