Unlike in Captain Underpants: The First Epic Movie (2017), in which they were voiced by adults, George and Harold are voiced by actual kids in this series.
This series takes place in Piqua Ohio. There is an actual town in Ohio named Piqua. However in the show the characters pronounce the name of the town incorrectly. In the show they pronounce the "i" in Piqua with a long e sound. The actual town is pronounced using a short i sound.
Jerome Horwitz elementary is named after Curly Howard of the Three Stooges. Jerome was Curly's real name.
There are only 2 episodes not to include Melvin
The last names of George Beard and Harold Hutchins come from Matthew 'Stymie' Beard and Bobby 'Wheezer' Hutchins, two actors in The Little Rascals (1955).