Audrey has a sister named Zoe in the series. Traditionally, Lil' Audrey has a brother she nicknamed Patches.
Little Audrey's iconic dress that she has worn in the comics and animated shorts have been replaced with a long sleeved shirt with a lightening bolt, pants and sneakers.
This series is the animated debut of Little Lotta and Little Dot, who have previously only appeared in the Harvey Comics.
Former boy band members Joey McIntyre, Nick Lachey, Joey Fatone, and Shawn Stockman provide the voices of the show's band Crush4U.
Lotta is the only Harvey comics character to have been adapted into live-action before animation. She, as well as Audrey, appeared in the straight-to-video release Baby Huey's Great Easter Adventure (1999).