The title ZeroZeroZero is a play on the Italian grading system for flour, which is rated, 2, 1, 0 or 00 depending on how refined it is (double zero being the highest grade). ZeroZeroZero, or triple Zero, here means pure cocaine.
Reportedly shot for a budget of almost 160 million dollars, making it one of, if not, the highest budget mini-series of all time.
The Don's car has the plate number 666 in it.
Over the course of this series shoot, Andrea Riseborough (Emma) also acted in The Kindness of Strangers (2019) and The Grudge (2019).