In contrast to the norm for animation, the cast recorded their voice roles together in groups rather than independently from one another. A single recording session could include up to seven actors. This environment allowed for the cast to play off each other as well as employ a lot of improvisation in their performances. According to Seth Rogen, "For every session, we lumped people together. We really went out of our way and bent over backward to try to capture that improvisational energy you get when a lot of people are in the same place at the same time."
Ice Cube agreed to play Superfly because he liked the name and because he and his son watched TMNT cartoons.
Despite a 30+ year career and over 130 acting credits to his name, Paul Rudd is given an introducing credit. Presumably a joke from long time collaborator Seth Rogen.
The filmmakers cited Spider-Man: Into the Spider-Verse (2018), the Jackie Chan martial arts films Police Story (1985) and Rumble in the Bronx (1995), the crime drama Chungking Express (1994), the period film Boogie Nights (1997), and the works of cinematographers Emmanuel Lubezki and Spike Jonze as an influence on the visual style of the film.