Based on real events happened in Kerala during May and June of 2018 which claimed 17 lives.
Revathi is seen hugging Madonna Sebastian, one of the 2 nipah survivors towards the end of the movie. In Tamil movie Pa.Pandi(2017) Madonna plays the younger version of Revathi.
6 Film directors have acted in Virus including Dileesh Pothan , Basil Joseph , Soubin Shahir, Zakariya Mohammed, Dileesh Nair and Revathi.
Rima Kallingal who played the nurse Akhila is also the producer of this movie.