Rather than read Marvel comics to prepare for the role of Agent Mobius, Owen Wilson instead had Tom Hiddleston explain the entire Marvel Cinematic Universe to him.
It's well known that Marvel is strict about spoilers getting out. Owen Wilson revealed he 'let it slip' that he grew a mustache for his character, Mobius. He said later that day, he received an ominous text from an unknown number saying "Strike 1". He said it might have been Kevin Feige using a burner phone and made sure he was careful when talking about Loki.
In the comics, each agent of the Time Variance Authority resembled Marvel Comics writer/editor Mark Gruenwald. This was a joke as Gruenwald's job as editor was to maintain continuity across the Marvel Universe.
The TV series is intended to have a major impact on the Marvel Cinematic Universe, serving as a link to Doctor Strange in the Multiverse of Madness (2022) and Ant-Man and the Wasp: Quantumania (2023).
The animated mascot Miss Minutes is inspired by the animated character Mr. DNA from Jurassic Park (1993).