Benedict Cumberbatch revealed in an interview that Benedict Wong broke about four ribs when he slammed into something during a stunt.
Sam Raimi initially didn't want to direct any future superhero films, having lost faith in himself due to the critical and audience backlash he received from Spider-Man 3 (2007) due to studio interference from Sony. However, getting the call from his agent about this film encouraged him to try again, as he had thoroughly enjoyed the first Doctor Strange film (as well as the character himself) and wanted to see if he could live up to the challenge of meeting the audience's expectations once again.
Director Sam Raimi previously added two references to the character Doctor Strange in Spider-Man 2 (2004):
- Joe's Pizza (where Peter Parker is working at the beginning) and the billboard showing Mary Jane are located on Bleecker Street (where Doctor Strange's Sanctum Santorum is located).
- The name of Doctor Strange is suggested to J. Jonah Jameson as a possible name for Dr. Octavius, to which Jameson replies: "But it's taken!"
Elizabeth Olsen flew to London to work on this film just two days after she finished filming WandaVision (2021).
Benedict Cumberbatch grew out Doctor Strange's goatee for real in this film, rather than merely putting on a fake one as seen in his previous appearances.
Michael Waldron: The film's writer plays Charlie's best man at the wedding. He appears on the balcony next to Christine.
Scott Spiegel: As the voice of one of the Souls of the Damned. Spiegel has been friends with Sam Raimi since high school, and they have collaborated on numerous films.
Sam Raimi: [Campbell] (at around 41 mins) Pizza Poppa is played to comic effect by Bruce Campbell. Raimi and Campbell have been friends since high school, and Campbell has appeared in nearly all of Raimi's films, including all three Spider-Man films.