Plot

Plagued by a recurring violent nightmare, a college student returns home to find the one person who can break the cycle and save her family from the horrific fate that inevitably awaits them.

A teenage girl has recurring nightmares of a tower collapse in the 1960s. She discovers that these nightmares are a premonition she inherited from her grandmother. The grandmother predicted the collapse of the building and saved a group of people from death. Decades later, the granddaughter begins to have visions of her family members dying. She realizes that there is a sequence and must fight to prevent Death from reclaiming her family's bloodline.—Horror Brains

In 1968, Iris Campbell and her fiance Paul attend the opening ceremony of the Skyview, a high-rise restaurant tower. At the dance party, Iris has a premonition of a chandelier's shard cracking the glass floor beneath the guests while a gas leak explodes, collapsing the tower and killing everyone.

In the present, college student Stefani Reyes suffers from recurring nightmares about the collapse. Realizing that the nightmares are linked to her maternal grandmother, Iris, she returns home seeking answers and is greeted by her father, Marty, and her estranged brother, Charlie. The siblings visit their uncle Howard, aunt Brenda, and cousins Erik, Julia, and Bobby. When Stefani asks Howard about Iris, he explains that Iris subjected him and Stefani's mother Darlene to an overprotective upbringing, then became reclusive, causing Darlene to abandon the family. Brenda helps Stefani find letters from Iris, leading her to a fortified cabin where Iris now lives.

Terminally ill, Iris tells Stefani she disrupted Death's design by preventing the tower's collapse, saving the lives of everyone there that night. As a result, Death began killing the survivors in the order they would've died at the Skyview, along with their descendants who were never meant to exist. Paul later died in an accident, prompting Iris to document Death's omens in a book and live in isolation to prevent it from going after her family. Though Stefani is skeptical, Iris leaves the cabin to give her the book and allows herself to be impaled by a weather vane to prove her claims.

After Iris's funeral, Darlene returns, but Stefani resents her for being absent ever since she was a child. Stefani reads Iris' book and sees a reference to someone Iris knew named JB, who found someone that defeated Death. During a family barbecue, a chain reaction causes Howard to be killed by a lawn mower. Stefani creates a diagram of all the families that were born because of her grandmother Iris and tries to explain death's design to her family. But they refuse to believe her thinking she is crazy and that Iris's death was just a horrific accident.

That night, another chain reaction causes a fire at Erik's tattoo shop, but he survives due to his leather clothing. Stefani and Charlie meet Erik on the road to protect him from street hazards, but instead witness Julia being accidentally thrown into a garbage truck and is unable to save her from being crushed to death by the garbage truck's compactor. The family finally realizes that Death is coming for them in order of age, starting with Howard's branch of the family before moving onto Darlene's. Marty and Brenda are spared, as they are not blood relatives, and Erik is spared due to being the result of Brenda's affair.

Darlene suggests visiting JB at a hospital, who turns out to be William Bludworth. Present at the Skyview as a child and the last to die in the premonition, he reveals that he spent most of his life exchanging ideas with Iris to learn Death's rules. He explains two ways to defeat Death: taking another life and gain their remaining time or dying and being revived, citing Kimberly Corman as a successful example. Retiring from his job as the mortician, Bludworth leaves the hospital, expecting to succumb to his own illness after Iris's bloodline dies, and wishes the family luck before departing.

Erik convinces Bobby to employ Bludworth's second strategy, where he feeds Bobby a snack containing nuts, which he is allergic to, so he could be subsequently revived. The plan backfires when a malfunctioning MRI machine rips Erik's piercings out, pulls him in, and impales him with a wheelchair. Another chain reaction causes a coil from a vending machine to be launched and drilled into Bobby's head. Despite Erik seemingly being safe, Stefani reasons that his intervention trying to help Bobby put him on the list too. Stefani, Charlie and Darlene decide to drive to Iris's fortified cabin, intending to hide from Death. The RV crashes, and Stefani's seat belt jams. The cabin explodes after a chain reaction, sending the RV into the water as Stefani begins to drown. Darlene saves Charlie and pleads with him to rescue Stefani before a lamp post bisects her. Charlie breaks the seat belt and successfully resuscitates Stefani with CPR.

A week later, while preparing for prom, the father of Charlie's date tells the siblings that Stefani's heart never stopped, meaning she was unconscious not dead when Charlie revived her. As a result, they both realize that death is still coming for them, a chain reaction causes a nearby train to derail, which the two manage to barely evade. They believe that they managed to cheat death again, but they learn too late that the chain reaction isn't over and are subsequently killed by falling logs and the screen fades to black.