This series takes place in the Earth-1226 version of the Marvel Universe, together with Hit-Monkey (2021).
M.O.D.O.K.'s children, Melissa & Louis, have both made up their own acronyms: Mental Entity Living to Induce Seriously Sinister Anarchy & Lanky Organism Undeniably Irresistible and Syphilitic.
Patton Oswalt previously played Hedges in Blade: Trinity (2004) (Earth-26320 version of the Marvel Universe); voiced Uncle Ben and the Scorpion in Spider-Man (2017) (Earth-17628); appeared as various members of the Koenig family in Agents of S.H.I.E.L.D. (2013) (Earth-199999); and voiced Pip the troll in Eternals (2021).
In February 2019, it was announced that Marvel Television was developing an adult animated television series based on M.O.D.O.K., with a series order at Hulu, along with ones based on Hit-Monkey, Tigra and Dazzler, and Howard the Duck, that were intended to lead up to a crossover special titled The Offenders. In December 2019, Marvel Television was folded into Marvel Studios, which carried subsequent oversight of the series. The following month, Marvel decided not to move forward with Howard the Duck, Tigra & Dazzler, and The Offenders. Only M.O.D.O.K. and Hit-Monkey (2021) went into production as planned.
Nathan Fillion also appeared on posters advertising a Simon Williams (Wonder Man) film festival, as Simon Williams in Guardians of the Galaxy Vol. 2 (2017). Unfortunately, this background element is impossible to see in the finished film.