Trivia

Pilot Robert Morgan named the aircraft after his girlfriend at the time, Margaret Polk, of Memphis, TN. Morgan chose the nose artwork from a 1941 illustration in "Esquire" magazine by famous pin-up artist George Petty. She is wearing a blue outfit on the port (left) side of the aircraft and a red one on the starboard (right) side.

The "Memphis Belle" seen in this film, a Boeing B-17F (serial #41-24485), was moved to the National Museum of the U.S. Air Force at Wright-Patterson Air Force Base, Dayton, OH, in October 2005 to undergo a multiyear restoration. The restoration was completed in 2018 and it was put on display at the museum on 17 May 2018. It is raised and supported on stilts to give the impression of flight.

One of William Wyler's cameramen was killed while flying in another B-17 during a combat mission over Germany when his plane was shot down.

The first movie to be reviewed on the front page of "The New York Times".

While the film purportedly chronicles the first American heavy bomber to complete 25 missions in WWII, that distinction actually belongs to the B-24 Liberator nicknamed "Hot Stuff". It completed its 25th mission on 2/7/43. The first B-17 to complete 25 missions was "Delta Rebel II" on 5/1/43. "Memphis Belle" completed its 25th mission on 5/19/43, nearly 3½ months after "Hot Stuff".