In the scene where Kharis trashes the Scripps Museum, Lon Chaney Jr. drove his fist through real glass--it was supposed to be breakaway glass, but the prop man forgot to replace it before shooting started--and a shard of it flew up and cut him through his mummy mask in his chin. In this scene, Kharis can be seen bleeding, and it's real blood.
Although there are rumors that Lon Chaney Jr.'s scenes in the "Mummy" series frequently used doubles for him, director Reginald Le Borg stated that Chaney did his own scenes in this film.
According to director Reginald Le Borg in a 1989 interview, Lon Chaney Jr., as Kharis, went overboard in the scene in which he strangles Frank Reicher, although Chaney blocked the camera from picking up Reicher's reaction. The veteran actor was moaning, and exclaimed, "He nearly killed me!" According to LeBorg, Reicher was a veteran and didn't make a formal complaint, but the next day the director noticed his neck visibly bore the effects.
The opening scene introduced Kharis simply walking out of the woods with no explanation or rationale. Director Reginald Le Borg was able to talk producer Ben Pivar into shooting a prologue set in Egypt with John Carradine and George Zucco in order to give Kharis' introduction a basis in logic.
Lon Chaney Jr. often said that being made up as the Mummy character was his least favorite make-up. There is a photo of the actor on set during production of "The Mummy's Ghost" where he is pinching his own nose in disgust.