May Robson (about 82 in this film) was in fact over a decade older than Richard Carle (about 69), who plays George, the butler who grew up with Cornelia Wheelwright's (Robson's) father.
Pam's address is given as 351 West 12th St. in Manhattan. That is in the middle of the block between Washington and Greenwich Streets in the Greenwich Village neighborhood.
At the end of the party scene the orchestra is playing the song "Moonlight and Tears". This is possibly a throwback to Priscilla Lane and Jeffrey Lynn's 1938 film "Four Daughters" in which Lynn's character writes that song.
The large flying boat shown landing at LaGuardia Airport in New York City is a Pan American Boeing 314 "Clipper". Only 12 were made from 1938 to 1941. Nine were operated by Pan Am, three by BOAC. None survived beyond 1951. Note the large Amercian flag painted on the nose for increased recognition, indicative this film was shot after the beginning of WW2 in Europe.
According to contemporary articles in The Hollywood Reporter, Irene Dunne was considered for the role of Pam. Ann Sheridan was originally cast for the part, but was replaced by Olivia de Havilland during Sheridan's contract dispute with the studio. Finally de Havilland was replaced by Priscilla Lane.