Although Joe Flynn played a serious role, audiences laughed at him. This convinced him that comedy was his forte, and he later specialized in comedic roles, most memorably as the irascible Capt. Binghamton in McHale's Navy (1962).
Lon Chaney Jr. reportedly asked director Jack Pollexfen not to make any dialogue changes or additions after the lunch break, when he usually drank heavily.
The full story of the making of the movie (complete with interviews with some of the participants) plus the script and pressbook are featured in the book "Scripts from the Crypt: 'Indestructible Man'" (BearManor, 2015) by Tom Weaver.
Lt. Chasen mentions putting in a call to a Prof. Dwiggins at CalTech, who may know about Prof. Bradshaw's work. Sue Dwiggins is the real name of co-writer Sue Bradford.
The exterior shots of the burlesque house, referred to as the Follies in the film, is the New Follies Burlesque at 548 South Main Street in downtown Los Angeles, formerly the Burbank Burlesque Theatre - not to be confused with the original Follies Theatre two blocks away at 337 South Main Street. The owners of the original Follies moved their operation to the Burbank in 1952 and renamed it the New Follies, which led to confusion when a new set of owners re-opened the Follies under its original name. Eventually the owners of the New Follies would change the name to the New Burbank Follies. The theater closed in 1971 and the building was demolished in 1974.