Three of the bikini girls from the bikini machine were Playboy playmates.
In a 1987 interview with David Del Valle, Vincent Price said of this film: "It could have been fun, but they cut all the music out."
Portraits of Goldfoot's ancestors include likenesses of various Vincent Price movie characters, including Verden Fell from The Tomb of Ligeia (1964) and Roderick Usher from House of Usher (1960).
The dungeon and torture sequence incorporates long shots of Vincent Price lifted from the The Pit and the Pendulum (1961). The torture chamber art and set direction was by the same art director, Daniel Haller, and these scenes evoked his work on other Edgar Allan Poe adaptations for Roger Corman, which also starred Vincent Price.
In the midst of the extensive, wacky vehicle chase about halfway through the movie, the various characters pass a movie marquee reading The Girl in the Glass Bikini. That title also appears in the end credits, being promoted as a sequel to star Annette Funicello, Deborah Walley, Harvey Lembeck, and Aron Kincaid. A sequel was made, but none of the promised actors appeared in it and the title was changed to Dr. Goldfoot and the Girl Bombs (1966).
Annette Funicello: a girl in the dungeon. Only her head and hands are visible in the pillory, which was designed to conceal her pregnant belly.
Harvey Lembeck: a motorcycle thug in the dungeon. Implicitly, he is Eric Von Zipper, his regular character from the Beach Party movies.
Alberta Nelson: the gruff-voiced robot #12 reject. Nelson played one of the Rat Pack motorcyclists in the Beach Party movies.