Director Larry Buchanan later went on record saying, "Never make a swamp picture. Your film comes back and it's all . . . strange".
Shot in Uncertain, TX, where the Fly-N-Fish Lodge and Airport seen in early scenes still exists.
The titular creature was created using primitive prosthetic make-up and grayish-green body paint, not the infamous scallop-scaled rubber wetsuit and fish head mask with fangs and painted ping-pong-ball eyes Larry Buchanan later used in Creature of Destruction (1968) and It's Alive! (1969).
The film re-uses Ronald Stein's music from It Conquered the World (1956), Invasion of the Saucer Men (1957) and The Terror (1963).
A "Curse of the Swamp Creature" mask was one of the last items produced by the famed Don Post Studios before it went out of business in 2012.