The character Oscar North was openly used as the pattern for Ted Baxter on the Mary Tyler Moore, which Leonard Stern, creator of this series, granted permission. Jack Cassidy, the star of this show, played Ted's brother Hal in one episode, Cover Boy (1971).
Co-stars Richard Benjamin and Paula Prentiss were married in real life. They married in 1961 and, as of this writing (2021), are still married.
Paula Prentiss accepted this role because she felt it would be therapeutic as an nonthreatening way to ease back into acting after a she suffered a nervous breakdown on the set of 1965's "What's New, Pussycat?", which virtually derailed her career for awhile.
The first and only weekly series role for Broadway musical comedy star Jack Cassidy. He once said he enjoyed comedy because the rewards are "instant." He had no desire to look out into an audience "to see if there are any tears."
"He & She" is widely considered by broadcast historians to have been ahead of its time. Its sophisticated approach to comedy was viewed as opening doors to the groundbreaking MTM family of sitcoms of the 1970s, beginning with "The Mary Tyler Moore Show" in 1970. Allan Burns, co-writer and story editor for "He & She", went on to co-create and write for "The Mary Tyler Moore Show".