The role of Dr. Seymour Love was originally to be played by Tyler Reynolds, but Reynolds was fired after conflicts with director Radley Metzger and the role was recast with Jamie Gillis.
Only Jamie Gillis was flown to Europe for the scenes shot in both Paris, France and Rome, Italy. Body doubles for Constance Money were used for all the shots of Money's character in both Paris and Rome.
Actor Jamie Gillis enters La Scarlett, the Parisian adult movie theater, at the beginning of Misty Beethoven. The theater's marquee indicates that the film showing is Le sexe qui parle (aka Pussy Talk). However, when inside, Gillis is watching something entirely different. The scene on the theater's screen was filmed just for Misty. The actress in the scene is not credited in Misty's on-screen credits. She can also be found (uncredited once again) in the film My Erotic Fantasies from the same year as Misty.
Ras Kean's character "Lawrence Layman" is a thinly veiled parody of real-life publisher Hugh Hefner.