Director Allan Holleb had recently graduated from UCLA. Julie Corman gave him the job on this film after being impressed by a short film he had made, Heavenly Star. Holleb later said "I found out they had taken a poll at a local high school. They sent someone out with a list of 30 or so titles and Candy Stripe Nurses got the most votes... They wanted a little social consciousness, a little romance, a little comedy and a little sex. Another requirement was they wanted a sex clinic. I don't know why."
The film was shot at a hospital in Burbank. The director Holleb said producer Julie Corman gave the board of directors an expurgated copy of the script under the title of Angels of Mercy to get permission. Holleb said the hospital was at 95% capacity during the shoot meaning there were frequent clashes between staff and crew. He said while shooting a scene in a linen closet with a topless Candice Rialson, someone from the linen service came in and saw her. Then an un-expurgated copy of the script was found and the unit was kicked out of the hospital. They had to move to another location, a former clinic, which did not match the original hospital. Holleb got the art director to put up a sign saying "this way to the new west wing" to justify the completely new look.
The scoreboard at the basketball game lists players for Cal Stat Northridge (left side) and Cal State Fullerton (right) who all played during the 1973 - 1974 season.
Much of the filming centered around the Burbank Community Hospital which stood at East Olive Ave & N 5th Street until 2001.