A few months before the series' debut, the Muppet Babies were introduced in a musical number in The Muppets Take Manhattan (1984).
In a 2016 interview, Dave Coulier revealed that he and Frank Welker were not allowed to sit together during recording sessions because they would inevitably ruin takes by making each other laugh.
The show made extensive use of clips from popular movies and Hollywood shorts to show the babies' imaginations. Problems with royalties and licensing the clips have kept the show out of syndicated reruns and seasonal DVD releases.
In the second season, the show was expanded to 60 minutes and the title was changed to "Muppets, Babies, & Monsters". An additional segment titled "Little Muppet Monsters" featured new puppet characters and animated segments. The segment was so unpopular that it was cancelled after two episodes. The remaining half-hour was filled with reruns from the first season. The show's closing theme song was changed to an instrumental version of the "Monsters" theme song, and it remained until the end of the show's run.
Skeeter is the only one of the main baby characters who was never made in an "adult" puppet form for The Muppets' standard appearances. She is unique to this animated version, and was created because the producers wanted another female character in the show, despite that there were several female muppets from The Muppet Show and movie adaptations and Janice appearing in one episode. She was voiced by men (Howie Mandel and Frank Welker), just like most of the adult female puppet characters.