The profit of this film was donated to cancer related charities. Sunil Dutt made this film to reflect the tough time he had during Nargis's illness.
Despite being one of the busiest heroines of the time with 14 releases to her credit that year, Reena Roy made a special concessions to act in a brief role in the movie. This was her way of showing gratitude to Sunil Dutt who had been instrumental in getting her several big movies when she was a struggling actress - Paapi, Zakhmee, Umar Qaid and even Nagin.
There were stories of Sunil Dutt wanting to sign Rekha for the film. But later back tracked due to stories of Sanjay and Rekha. Sunil Dutt said this was false and he never approached Rekha for the film.
The board of censorship gave this movie an Q certificate, it means Quality movie. Dard Ka Rishta is the only movie which was given this type of certificate by the censor board.
Johny Lever was launched in this film in a brief role.