Omega watches, worried about an association with a far right terrorist organisation took the film studio to court in a last ditch attempt to block the films release. Italian sports brand Kappa even stepped in with the offer of sponsorship to take the naming rights, contracts had been signed and 'Kappa Syndrome' wrap party t-shirts had even been ordered when Omega watches dropped their case. Omega watches CEO Tim E. Phlies, in an interview with Empire magazine would later laugh off the lawsuit when it was put to him that the total box office sales for the film came to less than the cost of one of his watches.
The original premise of the movie had Omega developing a viral weapon to wage in their terrorist activites, with Jessie to be used as a test subject, hence the title Omega 'Syndrome'. Colm Meaney's character was originally intended to be a biological warfare specialist. However when the original science advisor to the writing team, Dr Billy D. Phlash, died during a tragic roller coaster accident the director decided to take the plot in another direction. The title 'Omega Syndrome' remained as a touching tribute to Billy.
The blimp chase scene was the most difficult to film as the stunt crew had no prior experience driving stunt blimps. Their solution was to employ a trio of local drunks to fly around the city whilst they filmed. The resulting chase scene turned out rather well and incredibly there were no fatalities.
A Stargate video arcade is seen in the convenient store right when Jack and Jessie come in. The game came out in 1981.
Jack calls Jessie a Wise guy after she said that it would be really scary if she started growing whiskers. One year after this movie came out Ken Wahl starred in the TV show "Wiseguy(1987)."