The film was made and released about four years after its source novel "Slate and Me and Blanche McBride" by Georgia Savage had been first published in 1983. The source book's title in the film's credits is worded slightly differently as "Slate & Me and Blanche McBride".
Actress Sigrid Thornton and producer Tom Burstall are married. To date, Slate, Wyn & Me (1987) is their final cinema movie collaboration. Around the same time, the pair also worked together on Great Expectations: The Untold Story (1987) which debuted in the same 1987 year as Slate, Wyn & Me (1987).
Two endings for the movie were filmed with the one used in the final cut being an amalgam of the pair that had been shot.
According to Joanna Murray-Smith in the book 'Australian Film 1978-1994' (1995) edited by Scott Murray, in reference to the Jackson surnames of the two lead male characters of Wyn (Simon Burke) and Slate (Martin Sacks), who are the film's Jackson Brothers, "there is no mention of 'Jackson' in the credits, but the name is used throughout the film and is spelt thus in the press material".