The boat chase was filmed on the Cuyahoga River in Northeast Ohio. It climaxes with an explosion which used 700 gallons of gasoline combined with 200 gallons of alcohol. Despite warnings the night before on several news channels, the explosion caused Cleveland residents to panic, leading to 210 phone calls to emergency services for over ten minutes.
A video game featuring motion captured sprites like Mortal Kombat was concepted to coincide with the movie, having the actors of the film and their stunt doubles provide the captured images. However it was deemed it could not be completed in the same amount of time as the movie, so was scrapped. After the movie was released, the film studio admitted it was a stroke of luck the game didn't go ahead. The film would later have a Japan only, tie-in, fighting game of the same name, developed by Technos Japan under the license of SNK Playmore, ported to the Neo Geo MVS and the Neo-Geo CD in 1995 as well as the PlayStation in 1996.
Alyssa Milano and Scott Wolf actually started dating while filming this movie and were subsequently engaged, but the relationship didn't last and the couple eventually broke up.
Dozens of arcade games appear in the Power Corps hideout. DOUBLE DRAGON is one of them as a fourth wall-break. It's visible when Jimmy (possessed by Kogo Shuko) tries to kick Billy but misses and shatters the monitor of the machine.
Unlike the game, the film takes place in the apocalyptic future of 2007 in Los Angeles, California known fictionally as "New Angeles".