Trivia

The Learjet featured in the movie was owned by John Travolta at the time the movie was made. Tail number N254JT. JT = John Travolta.

In some early trailers Richard Pryor did the voice of Eddie.

Richard Pryor was offered the voice role of Eddie, but turned it down due to ill health.

In a 2016 interview with The Current, an online publication of The Criterion Collection, Amy Heckerling mentions that she had "sort of been forced into doing a sequel to Look Who's Talking (1989) for legal reasons, and it was just like, the story is over. That was not a fun experience."

James refers to Stuart as "Travis Bickle" (referencing the movie Taxi Driver (1976)) during an argument with Mollie. Ironically James's former occupation was as a taxi driver.