During production Doris was making a good living as a call boy and funding for the film came from their earnings. Doris once said "Who said you couldn't make a film on a prostitute's salary."
Most of the film was shot in Doris and Ginger's flat at 422 Oak Street San Francisco, CA.
Producers intended to use the medley from the cast's nightclub show for the big musical number near the end of the film. The medley included brief passages from many well-known show tunes. Due to Doris Fish's death and the high cost of the rights to even fragments of those songs, the scene had to be post-dubbed, with a different song and alternate singers.
The principal photography of "Vegas in Space" spanned 18 months, but it took Fish and Ford eight years to raise the funds to complete the film.
For the opening scene of the film, The Spaceship Sequence, Doris had found the set pretty much intact and purchased it from a commercial display store.