Alicia Silverstone turned down the offer to appear on this show, preferring to continue with her film career.
Stacey Dash, Donald Faison, Elisa Donovan, Twink Caplan, and Wallace Shawn are the only regular cast members who also appeared in Clueless (1995). Paul Rudd, Breckin Meyer, and Brittany Murphy made guest appearances as different characters.
The high school where the students attend in both the movie and this TV series is "Bronson Alcott High School." Bronson Alcott was a nineteenth-century Transcendentalist writer, best known for starting an ultimately unsuccessful Utopian community called "Fruitlands," and for being the father of "Little Women" author Louisa May Alcott. At one time, Amy Heckerling dated Bronson Pinchot, whose middle name is "Alcott," after the author.
Numerous actors from the film, such as Paul Rudd and Breckin Meyer, guest-starred on the series playing other characters.