Daniel Benzali was allegedly fired from the show for being late by an hour every day of production. When Steven Bochco asked him about it Benzali said he was consistently late because "[he] had to wait until [he] had his morning dump" before coming to set.
Was chosen by Time Magazine as one of the "Best of Television 1996" at position #4 in the in their year end review issue dated December 23, 1996.
Several early episodes make reference to "the Anselmo case", a running gag from Moonlighting (1985), for which Murder One co-creator Charles H. Eglee was a writer.
Early on, Steven Bochco intended to cast a supermodel as Julie, and Claudia Schiffer and Vendela Kirsebom even auditioned for the role.
The character of Louis was originally going to be a female character.