Patrick Dempsey was hired the day before shooting began. He had one night to learn three big dialogue-heavy scenes.
David Arquette and Courteney Cox met on the set of Scream (1996), dated while shooting Scream 2 (1997), and married a month before principal photography of this movie began. They cut short their honeymoon in order to film it. Cox added "Arquette" to her name, as seen in the credits.
(At around sixteen minutes) The green outfit worn by Parker Posey while on-set is the same one worn by Courteney Cox in Scream (1996). All sets for "Stab 3" were replicas of the originals, since the sets were destroyed after Scream (1996) wrapped.
The house used during the climax, where most of the killing takes place, is the same house used as a school in Halloween H20: 20 Years Later (1998). The house would later be used again for the ending of The Neon Demon (2016).
The publicity stills of young Maureen Prescott, or "Rina Reynolds", are actually early modelling photos of a young Lynn McRee, the actress who portrayed the adult Maureen Prescott.
Jason Mewes, Kevin Smith: (At around nineteen minutes) Jay and Silent Bob, the popular drug dealer characters from Clerks (1994) and other movies, appear as tourists visiting Sunrise Studios who spot Gale Weathers (Courteney Cox) and mistake her for Connie Chung.