According to Tom Sizemore, he and Marc Anthony did not get along and almost had a physical altercation on the set.
Martin Scorsese has admitted that he didn't enjoy shooting the film at all. Most of it was filmed at night in mid-December so conditions were continually harsh.
Martin Scorsese and Nicolas Cage rode along with real NYC paramedics in preparation for filming.
Every night during filming, Nicolas Cage would go through an average of ten shirts through a combination of blood, sweat and mud.
In the scene where Frank attempts to save Rose, the actors acted out their movements in reverse. The sequence itself was then played in reverse. This adds to the dreamlike effect of the scene in which the snow rises.