A full-scale python head was constructed and used during filming, but never once is seen on-screen in the final cut.
William Zabka (Greg) plays the ex-boyfriend of Dana Barron (Kristin). Zabka was also in National Lampoon's European Vacation (1985), playing the boyfriend of Audrey, the character Barron played in National Lampoon's Vacation (1983). Although she didn't return for the sequel, the actress who took over for her was also named Dana (Dana Hill)
William Zabka was in the movie The Karate Kid and the Netflix TV show Cobra Kai. A cobra is a type of snake.
Both William Zabka (villain in Karate Kid) and Pat Morita (hero in Karate Kid) have been in movies about giant snakes. Zabka in Python & Python II, Morita in King Cobra.