Dana Snyder got the job of voicing Master Shake through an old college friend, who went to high school with director Dave Willis. Willis was looking for voice actors and asked her if she knew anyone with a weird voice, and she recommended Snyder. His first "audition" was leaving a drunken, abusive, message on Dave Willis' voice mail at 3 am. Willis loved it but accidentally erased the recording and asked him to re-record it, which he did, but sober this time. Willis wasn't as keen on the second recording so he asked him to do it like he did the first time. Snyder dutifully went out with some friends, got drunk, and left another 3 am message. He was given the job.
Schoolly D wrote the show's theme song while riding in a limo to the studio on the same day it was to be recorded. Dave Willis and Matt Maiellaro provided the backup vocals.
The mall in the first episode is taken from the pilot episode of The Powerpuff Girls (1998). It even says "Powerpuff Mall" on the side of the building.
When the teens move around, they make sounds according to the food that they are. Meatwad, for instance, makes a squishy sound. The creators actually bought eight pounds of hamburger meat and squished it with rubber gloves to get that sound. They also bought a milkshake to get some sounds for Master Shake.
The show was created using Adobe Photoshop images, animated using Adobe After Effects, and edited using Apple's Final Cut Pro. Writing the script took Dave Willis and Matt Maiellaro around four or five weeks, after which they spent another week making an animated rough draft video and getting the voiceover work done. Animators then used the QuickTime draft video as a reference, spending another five weeks making the finished 11 minute episodes. The entire process cost around $60,000 per episode, which is/was an uncommonly low figure for an animated TV series.