Dee Dee only spoken line in the film is her catchphrase, "Oooh, what does this button do?"
Intended to be the series finale of Dexter's Laboratory (1996), creator Genndy Tartakovsky left the series to work on other projects such as Samurai Jack (2001) and Star Wars: Clone Wars (2003). Due to the series' popularity, writer and storyboard artist Chris Savino revived the series for a third and fourth season from late 2001 until 2003.
This is the final installment of the series to use traditional cel animation. Digital coloring began with the revived series in 2001, starting with Streaky Clean/A Dad Cartoon/Sole Brother (2001).
Craig McCracken co-directed the film but he was uncredited. He began working on the next project of The Powerpuff Girls Movie (2002) along with Genndy Tartakovsky, three years after the movie was done.