The first Scooby-Doo series to abandon many of the classic Hanna-Barbera sound effects, which were a trademark of the previous series that Hanna-Barbera Productions produced. Although a small portion of the Hanna-Barbera library is still used, new Foley effects were recorded and created exclusively for the series to make it sound more "realistic" and "updated", compared to the older, more "cartoony" series.
The first Scooby-Doo series not produced by Hanna-Barbera Productions, even though the series is still copyrighted by them; Warner Bros. Animation (the unit responsible for Tiny Toon Adventures (1990) and Animaniacs (1993) and many classic Looney Tunes shorts, among many others) did the production work, having assumed production on the Scooby-Doo franchise since Scooby-Doo on Zombie Island (1998). Warner Bros. Animation had absorbed Hanna-Barbera Productions in 2001 following the death of William Hanna since the A Pup Named Scooby-Doo (1988), the television film Scooby-Doo in Arabian Nights (1994), and the previous four DTV Scooby-Doo movies.
Scott Innes did not reprise his role as Scooby-Doo for the series, so the creators of the series were thinking of replacing Innes with Marty Grabstein. However, Grabstein was too busy voicing his other cartoon dog character Courage the Cowardly Dog (1999). The role for Scooby-Doo went to Frank Welker.
The first time since 1995 that Casey Kasem has done the voice of Shaggy. You will also notice that Shaggy is a strict vegetarian on this series. See the trivia for Scooby Doo, Where Are You! (1969).
This series marks the first time Mindy Cohn voices Velma, and the first time Frank Welker voices Scooby-Doo.