In 2002, Wright accidentally named John Leslie on-air as the television presenter being linked to the alleged rape of Ulrika Jonsson. Leslie's career never recovered.
In 2014, Wright abruptly cut off a caller after being outraged when she said she didn't want her child to be taught about homosexuals at school.
On 6 March 2018, Iain Lee appeared as the special guest but walked off during the first commercial break after taking exception to a repeated line of questioning from host Matthew Wright.
The series is broadcast live without a delay, which has resulted in a number of occasions when the series has accidentally broadcast foul language. Wright had to apologise after special guest Giles Coren repeatedly used a vulgar term for oral sex while he was being interviewed and Rula Lenska accidentally uttered "bollocks" on the programme. Several callers to the programme have used foul language deliberately to cause offence.
In February 2015, Wright stated as a fact on the show that the late Sir Jimmy Savile had conned charities into believing he had run marathons which he hadn't actually run. However, while Savile has been posthumously proven to be a paedophile and necrophiliac whose charity fundraising was designed to gain access to vulnerable people, any accusations that he deceived charities over completing his marathons are tenuous and have not been proven.