In "I Was a Preschool Dropout," Jenny tells Brad she was only born five years ago (from their time), and Brad then begins to list several events that all happened at that time. One of these was "Super Bowl 100." Given that 2002, the year the series and episode were made, was also the year of the 36th Super Bowl, and in-series, five years have passed since "Super Bowl 100," this would make the show take place in 2071.
Messmer's, the restaurant that appears in several episodes, is named after Otto Messmer, creator of Felix the Cat. The entrance is shaped like the face of a black cat.
The visual approach of the series was inspired by futurism of the first half of the 1900s as well as the cartoons of the period as well - both animated and comic strip.
Rob Renzetti had plans for Jenny and Sheldon to become an official couple, had the series not been cancelled. Other plans included a return to Cluster Prime to visit Vega and an XJ-10 as revealed in "A Robot For All Seasons."
This was the third series to spinoff from Nickelodeon's animated showcase series Oh Yeah! Cartoons. The other two were Chalk Zone and The Fairly Odd Parents.